Floxin (Ocuflox, Ofloxacin)

Floxin Review

Floxin is used for treating mild to moderate infections caused by certain bacteria.

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Floxin Drug Class and Mechanism

Floxin is a fluoroquinolone antibiotic. It kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Floxin Uses

Ofloxacin should not be taken with food. Ofloxacin is partially metabolized by the liver and excreted by the kidney. Dosages require adjustment in patients with severely abnormal liver or kidney function. Antacids, minerals, and vitamins with iron block the absorption of ofloxacin and they should not be taken together.

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Floxin Side Effects

The most frequent side effects include nausea, vomiting, diarrhea, insomnia, headache, dizziness, itching, and vaginitis in women. Rare allergic reactions have been described, such as hives and anaphylaxis (shock). Symptoms of nervous system stimulation, such as anxiety, euphoria, and hallucinations have rarely been reported.

Floxin Pregnancy

Ofloxacin has not been shown to have any teratogenic effects at oral doses as high as 810 mg/kg/day (11 times the recommended maximum human dose based on mg/m? or 50 times based on mg/kg) and 160 mg/kg/day (4 times the recommended maximum human dose based on mg/m? or 10 times based on mg/kg) when administered to pregnant rats and rabbits, respectively. Additional studies in rats with oral doses up to 360 mg/kg/day (5 times the recommended maximum human dose based on mg/m? or 23 times based on mg/kg) demonstrated no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. Doses equivalent to 50 and 10 times the recommended maximum human dose of ofloxacin (based on mg/kg) were fetotoxic (i.e., decreased fetal body weight and increased fetal mortality) in rats and rabbits, respectively. Minor skeletal variations were reported in rats receiving doses of 810 mg/kg/day, which is more than 10 times higher than the recommended maximum human dose based on mg/m?.

Floxin Overdose

Information on overdosage with ofloxacin is limited. One incident of accidental overdosage has been reported. In this case, an adult female received 3 grams of ofloxacin intravenously over 45 minutes. A blood sample obtained 15 minutes after the completion of the infusion revealed an ofloxacin level of 39.3 ?g/mL. In 7 h, the level had fallen to 16.2 ?g/mL, and by 24 h to 2.7 ?g/mL. During the infusion, the patient developed drowsiness, nausea, dizziness, hot and cold flushes, subjective facial swelling and numbness, slurring of speech, and mild to moderate disorientation. All complaints except the dizziness subsided within 1 h after discontinuation of the infusion. The dizziness, most bothersome while standing, resolved in approximately 9 h. Laboratory testing reportedly revealed no clinically significant changes in routine parameters in this patient.

Floxin More Information

If you have any questions about Floxin, please talk with your doctor, pharmacist, or other health care provider. Floxin is to be used only by the patient for whom it is prescribed. Do not share it with other people.